Hear from a real patient with CLL

Descriptive Transcript
00:00 - 00:21

[Music begins playing as a green line starts forming a silhouette of Terry. The indication and Jaypirca logo appear on the screen.]

Caption:
Indication
Jaypirca is a prescription medicine used to treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or did not respond to previous treatment and who have already been treated with a BTK inhibitor for their cancer.

It is not known if Jaypirca is safe and effective in children.

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator: Jaypirca is a prescription medicine used to treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or did not respond to previous treatment and who have already been treated with a BTK inhibitor for their cancer.

00:22 - 00:28

[Music continues playing as the silhouette disappears.]

Caption:
Real Patient Stories
Terry's CLL Diagnosis
Chapter 1

It is not known if Jaypirca is safe and effective in children.

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

00:29 - 00:32

[Terry sits indoors with a sofa behind him. As Terry speaks, a speech bubble appears that reads, "I was diagnosed with CLL in 2000."]

Caption: Individual results may vary. Statements in this video are unique to Terry's experience on Jaypirca. Patient was compensated for his time.

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: My name is Terry and I was diagnosed with CLL in 2000.

00:33 - 00:45

[Video zooms in and out as Terry sits indoors.]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: And the doctor I had—was a great doctor—and he had noticed that my white blood count had gone up, increased by maybe a thousand a year over the last three years.

00:46 - 00:55

[Video zooms in as Terry sits indoors.]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: And he said, "Well, just out of caution, I'm going to send you to a hematologist." And so, they made an appointment for me with the hematologist.

00:56 - 01:06

[Video zooms out as Terry sits indoors. As Terry speaks, a speech bubble appears that reads, "He had told me nothing is going on here."]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: Two weeks later, I went back to see him by myself because he had told me nothing is going on here. And I just thought I was going to, you know, need to take iron or cut back on some food.

01:07 - 01:16

[Terry continues sitting indoors. As Terry speaks, a speech bubble appears that reads, "You have chronic lymphocytic leukemia."]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: And so, he came into the office, and he said, "Well, I was wrong. There is something going on here," and he said, "You have chronic lymphocytic leukemia."

01:17 - 01:24

[Terry continues sitting.]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: And so, I'm sitting there by myself in the office and he's telling me that I have leukemia.

01:25 - 01:29

[Terry continues sitting indoors. As Terry speaks, a speech bubble appears that reads, "Right now, it's pretty much incurable."]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: And he proceeds to also tell me that, "Right now, it's pretty much incurable."

01:30 - 01:47

[Video zooms in as Terry sits indoors.]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: When he told me that I had chronic lymphocytic leukemia, he actually explained that it was a very slow-growing cancer, that some people actually wind up living with it, and never needing treatment.

01:48 - 01:53

[Terry continues sitting indoors. As Terry speaks, a speech bubble appears that reads, "I thought to myself, 'I'm going to be one of the lucky ones'..."]

Caption: Please see Safety Summary for Jaypirca at the end of this video.

Terry: I thought to myself, "Of course, well, I'm going to be one of the lucky ones, and I'm not going to need treatment, I'm going to ride this out."

01:54 - 01:57

Caption:
Terry's story doesn't end here.
Learn more about Terry at: Jaypirca.lilly.com/patient-stories

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Caption: Please see Safety Summary for Jaypirca at the end of this video.

01:58 - 02:58

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
INDICATION AND SAFETY SUMMARY
Jaypirca is a prescription medicine used to treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or did not respond to previous treatment and who have already been treated with a BTK inhibitor for their cancer.

It is not known if Jaypirca is safe and effective in children.

Warnings - Jaypirca may cause serious side effects, including:

Infections. Infections can happen during treatment with Jaypirca. These infections can be serious and may lead to death. Your doctor may prescribe vaccines and certain medicines if you have an increased risk of getting infections. Tell your doctor right away if you have fever, chills, weakness, flu-like symptoms, or any other signs of infection during treatment with Jaypirca.

02:59 - 03:52

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Bleeding problems (hemorrhage). Bleeding problems can happen during treatment with Jaypirca.

They can be serious and may lead to death. Your risk of severe bleeding may increase if you are also taking a blood thinner medicine. Tell your doctor if you have any signs or symptoms of bleeding, including:

blood in your stools or black stools (looks like tar)
pink or brown urine
unexpected bleeding, or bleeding that is severe or you cannot control
vomit blood or vomit blood that looks like coffee grinds
cough up blood or blood clots
increased bruising
dizziness
weakness
confusion
changes in your speech
headache that lasts a long time

03:53 - 04:48

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Decrease in blood cell counts. Decrease in white blood cells, platelets, and red blood cells are common with Jaypirca, but can also be severe. This may increase your risk of infection, bleeding, and anemia. Your doctor should do blood tests regularly during treatment to monitor your counts.

Heart rhythm problems. Heart rhythm problems including atrial fibrillation and atrial flutter have happened in people treated with Jaypirca. Your risk for heart rhythm problems may be increased if you have high blood pressure or have had heart rhythm problems in the past. Tell your doctor if you have any of the following symptoms:

fast or irregular heartbeat (palpitations)
dizziness
fainting
chest discomfort
shortness of breath

04:49 - 05:48

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Second primary cancers. New cancers have happened during treatment with Jaypirca, including cancers of the skin or other organs. Your doctor will check you for other cancers during treatment. Use sun protection when you are outside in sunlight.

Liver Problems. Liver problems, which may be severe or life-threatening, or lead to death, can happen in people treated with Jaypirca. Your doctor will do blood tests to check your liver before and during treatment with Jaypirca. Tell your doctor or get medical help right away if you have any signs of liver problems, including stomach pain or discomfort, dark-colored urine, or yellow skin and eyes.

Your doctor may decrease your dose, temporarily stop, or permanently stop treatment with Jaypirca if you develop severe side effects.

05:49 - 07:56

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Common side effects

decreased white blood cell count
decreased red blood cell count
tiredness
decreased platelet count
decreased calcium

These are not all the possible side effects with Jaypirca. Call your doctor for medical advice about side effects. You may report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using
Before taking Jaypirca, tell your doctor about all your medical conditions, including if you:

have an infection or have been advised that you are at increased risk of infection
have had recent surgery or plan to have surgery. Your doctor may stop Jaypirca for a planned medical, surgical, or dental procedure
have bleeding problems and/or are taking blood thinner medicine
have or have had heart rhythm problems
have high blood pressure
have a history of other cancers, including skin cancer
have kidney problems
have liver problems
are pregnant or plan to become pregnant. Jaypirca can harm your unborn baby. If you are able to become pregnant, your doctor will do a pregnancy test before starting treatment

Females who are able to become pregnant should use effective birth control (contraception) during treatment and for at least 1 week after the last dose of Jaypirca. Tell your doctor right away if you become pregnant or think you are pregnant during treatment

are breastfeeding or plan to breastfeed. It is not known if Jaypirca passes into breast milk. Do not breastfeed during treatment and for at least 1 week after your final dose

07:57 - 09:03

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Also tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Jaypirca with certain other medicines may affect how Jaypirca or the other medicines work and can cause side effects.

How to take

Take Jaypirca exactly as your doctor tells you
Do not change your dose or stop taking Jaypirca unless your healthcare provider tells you to do so
Take Jaypirca 1 time each day at about the same time each day
Take Jaypirca with or without food
Swallow Jaypirca whole with water. Do not cut, crush, or chew the tablets
If you miss a dose of Jaypirca, take it as soon as you remember on the same day. If you miss taking a dose by more than 12 hours from the time you usually take Jaypirca, skip the missed dose. Take the next dose on the next day at your usual time

09:04 - 09:49

[Jaypirca logo in top-right of screen.]

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Narrator:
Jaypirca is a prescription medicine. For more information, call 1-800-545-5979 or go to www.jaypirca.lilly.com. This summary provides basic information about Jaypirca but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Jaypirca and how to take it. Your doctor is the best person to help you decide if Jaypirca is right for you.

Caption: PT CON BS CLL DEC2025

09:50 - 09:56

[Red Lilly logo in middle-left of screen; Jaypirca logo in middle-right of screen. Music ends.]

Caption: Lilly | A MEDICINE COMPANY

Caption: Jaypirca^® | pirtobrutinib | 50,100mg tablets | A Lilly Medicine

Caption: Jaypirca^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Learn about taking Jaypirca

SAFETY SUMMARY

Warnings - Jaypirca may cause serious side effects, including:

Bleeding problems (hemorrhage). Bleeding problems can happen during treatment with Jaypirca. They can be serious and may lead to death. Your risk of severe bleeding may increase if you are also taking a blood thinner medicine. Tell your doctor if you have any signs or symptoms of bleeding, including:

blood in your stools or black stools (looks like tar)
pink or brown urine
unexpected bleeding, or bleeding that is severe or you cannot control
vomit blood or vomit blood that looks like coffee grinds

cough up blood or blood clots
increased bruising
dizziness
weakness
confusion
changes in your speech
headache that lasts a long time

Decrease in blood cell counts. Decrease in white blood cells, platelets, and red blood cells are common with Jaypirca, but can also be severe. This may increase your risk of infection, bleeding, and anemia. Your doctor should do blood tests regularly during treatment to monitor your counts.

fast or irregular heartbeat (palpitations)
dizziness
fainting

chest discomfort
shortness of breath

Second primary cancers. New cancers have happened during treatment with Jaypirca, including cancers of the skin or other organs. Your doctor will check you for other cancers during treatment. Use sun protection when you are outside in sunlight.

Your doctor may decrease your dose, temporarily stop, or permanently stop treatment with Jaypirca if you develop severe side effects.

Common side effects

decreased white blood cell count
decreased red blood cell count
tiredness

decreased platelet count
decreased calcium

These are not all the possible side effects with Jaypirca. Call your doctor for medical advice about side effects. You may report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Before taking Jaypirca, tell your doctor about all your medical conditions, including if you:

have an infection or have been advised that you are at increased risk of infection
have had recent surgery or plan to have surgery. Your doctor may stop Jaypirca for a planned medical, surgical, or dental procedure
have bleeding problems and/or are taking blood thinner medicine
have or have had heart rhythm problems
have high blood pressure
have a history of other cancers, including skin cancer
have kidney problems
have liver problems
are pregnant or plan to become pregnant. Jaypirca can harm your unborn baby. If you are able to become pregnant, your doctor will do a pregnancy test before starting treatment
- Females who are able to become pregnant should use effective birth control (contraception) during treatment and for at least 1 week after the last dose of Jaypirca. Tell your doctor right away if you become pregnant or think you are pregnant during treatment
are breastfeeding or plan to breastfeed. It is not known if Jaypirca passes into breast milk. Do not breastfeed during treatment and for at least 1 week after your final dose

Also tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Jaypirca with certain other medicines may affect how Jaypirca or the other medicines work and can cause side effects.

How to take

Take Jaypirca exactly as your doctor tells you
Do not change your dose or stop taking Jaypirca unless your healthcare provider tells you to do so
Take Jaypirca 1 time each day at about the same time each day
Take Jaypirca with or without food
Swallow Jaypirca whole with water. Do not cut, crush, or chew the tablets
If you miss a dose of Jaypirca, take it as soon as you remember on the same day. If you miss taking a dose by more than 12 hours from the time you usually take Jaypirca, skip the missed dose. Take the next dose on the next day at your usual time

Learn more

Jaypirca is a prescription medicine. For more information, call 1-800-545-5979 or go to www.jaypirca.lilly.com. This summary provides basic information about Jaypirca but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Jaypirca and how to take it. Your doctor is the best person to help you decide if Jaypirca is right for you.

PT CON BS COMBO DEC2025

Jaypirca^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

INDICATIONS

Jaypirca^® (JAY-PIHR-KAA) is a prescription medicine used to treat adults with

mantle cell lymphoma (MCL) that has come back or did not respond to previous treatment and who have already received at least 2 treatments for their cancer, including a Bruton tyrosine kinase (BTK) inhibitor medicine.

Jaypirca was approved for this indication based on how many people responded to treatment. Studies are ongoing to confirm the benefit of Jaypirca for this use.

chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or did not respond to previous treatment and who have already been treated with a BTK inhibitor for their cancer.

It is not known if Jaypirca is safe and effective in children.